100-200mg of tocotrienol per day is adequate for lipid antioxidant protection for all cell membranes and lipoproteins.
The annatto tocotrienol known as DeltaGold® was granted FDA-affirmed GRAS in 2014 and has been proven safe in a variety of clinical trials up to 600mg/day.
Studies estimate the safe dose of tocotrienols for humans may be as high as 1,000mg/day.